|
|
Substance Name: Metolazone [USAN:USP:INN:BAN:JAN]
RN: 17560-51-9
UNII: TZ7V40X7VX
InChIKey: AQCHWTWZEMGIFD-UHFFFAOYSA-N
Note
- A quinazoline-sulfonamide derived DIURETIC that functions by inhibiting SODIUM CHLORIDE SYMPORTERS.
Molecular Formula
- C16-H16-Cl-N3-O3-S
Molecular Weight
- 365.839
- All
- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Antihypertensive
- Antihypertensive Agents
- Cardiovascular Agents
- Diuretic
- Diuretics
- Drug / Therapeutic Agent
- Human Data
- Membrane Transport Modulators
- Natriuretic Agents
- Reproductive Effect
- Sodium Chloride Symporter Inhibitors
* denotes mobile formatted website
Links to Resources
NLM Resources (File Locators)
Regulatory Agencies (Superlist Locators)
Other Resources (Internet Locators)
Search for this InChIKey on the Web
Names and Synonyms
Name of Substance
- Metolazone
- Metolazone [USAN:USP:INN:BAN:JAN]
MeSH Heading
- Metolazone
Synonyms
- 2-Methyl-3-o-tolyl-6-sulfamyl-7-chloro-1,2,3,4-tetrahydro-4-quinazolinone
- 5-25-09-00212 (Beilstein Handbook Reference)
- 6-Quinazolinesulfonamide, 7-chloro-1,2,3,4-tetrahydro-2-methyl-3-(2-methylphenyl)-4-oxo-
- 6-Quinazolinesulfonamide, 7-chloro-1,2,3,4-tetrahydro-2-methyl-4-oxo-3-o-tolyl-
- 7-Chloro-1,2,3,4-tetrahydro-2-methyl-3-(2-methylphenyl)-4-oxo-6-quinazolinesulfonamide
- 7-Chloro-1,2,3,4-tetrahydro-2-methyl-4-oxo-3-o-tolyl-6-quinazolinesulfonamide
- BRN 0965506
- Diulo
- EINECS 241-539-3
- HSDB 3367
- Metalozone
- Metenix
- Metolazona
- Metolazona [INN-Spanish]
- Metolazone
- Metolazonum
- Metolazonum [INN-Latin]
- Microx
- Mykrox
- NSC 759581
- Oldren
- SR 720-22
- UNII-TZ7V40X7VX
- Zaroxolyn
Systematic Names
- 6-Quinazolinesulfonamide, 1,2,3,4-tetrahydro-7-chloro-2-methyl-4-oxo-3-o-tolyl-
- 6-Quinazolinesulfonamide, 7-chloro-1,2,3,4-tetrahydro-2-methyl-3-(2-methylphenyl)-4-oxo-
- Metolazone
Registry Numbers
CAS Registry Number
- 17560-51-9
FDA UNII
- TZ7V40X7VX
System Generated Number
- 0017560519
Structure Descriptors
InChI
InChI=1S/C16H16ClN3O3S/c1-9-5-3-4-6-14(9)20-10(2)19-13-8-12(17)15(24(18,22)23)7-11(13)16(20)21/h3-8,10,19H,1-2H3,(H2,18,22,23)InChIKey
AQCHWTWZEMGIFD-UHFFFAOYSA-NSmiles
CC1Nc2cc(Cl)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
man | TDLo | oral | 2mg/kg/2W-I (2mg/kg) | VASCULAR: STRICTIRA; CJAMGES OM VESSE;S | Postgraduate Medical Journal. Vol. 67, Pg. 860, 1991. |
mouse | LD50 | intraperitoneal | > 1500mg/kg (1500mg/kg) | United States Patent Document. Vol. #3360518, | |
mouse | LD50 | intraperitoneal | > 1500mg/kg (1500mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | United States Patent Document. Vol. #3360518, |
mouse | LD50 | oral | > 5gm/kg (5000mg/kg) | United States Patent Document. Vol. #3360518, | |
mouse | LD50 | subcutaneous | > 5gm/kg (5000mg/kg) | Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 24, Pg. 261, 1982. | |
rat | LD50 | intraperitoneal | > 5gm/kg (5000mg/kg) | Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 24, Pg. 261, 1982. | |
rat | LD50 | oral | > 5gm/kg (5000mg/kg) | Drugs in Japan Vol. 6, Pg. APP-20, 1982. | |
rat | LD50 | subcutaneous | > 5gm/kg (5000mg/kg) | Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 24, Pg. 261, 1982. | |
women | TDLo | oral | 150ug/kg (0.15mg/kg) | BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: GENERAL ANESTHETIC | British Medical Journal. Vol. 1, Pg. 1381, 1976. |
Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
Melting Point | 256 | deg C | EXP | |
log P (octanol-water) | 1.840 | (none) | EST | |
Water Solubility | 60.3 | mg/L | 25 | EXP |
Atmospheric OH Rate Constant | 9.53E-11 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.