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Substance Name: Lamotrigine [USAN:USP:INN:BAN]
RN: 84057-84-1
UNII: U3H27498KS
InChIKey: PYZRQGJRPPTADH-UHFFFAOYSA-N
Note
- A phenyltriazine compound, sodium and calcium channel blocker that is used for the treatment of SEIZURES and BIPOLAR DISORDER.
Molecular Formula
- C9-H7-Cl2-N5
Molecular Weight
- 256.0953
Classification Codes
- Anticonvulsant
- Anticonvulsants
- Antipsychotic Agents
- Calcium Channel Blockers
- Calcium-Regulating Hormones and Agents
- Cardiovascular Agents
- Central Nervous System Agents
- Central Nervous System Depressants
- Drug / Therapeutic Agent
- Excitatory Amino Acid Antagonists
- Human Data
- Membrane Transport Modulators
- Neurotransmitter Agents
- Psychotropic Drugs
- Sodium Channel Blockers
- Tranquilizing Agents
- Voltage-Gated Sodium Channel Blockers
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Names and Synonyms
Name of Substance
- Lamotrigine
- Lamotrigine [USAN:USP:INN:BAN]
MeSH Heading
- Lamotrigine
Synonyms
- 3,5-Diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine
- 3,5-Diamino-6-(2,3-dichlorophenyl)-as-triazine
- 6-(2,3-Dichlorophenyl)-1,2,4-triazine-3,5-diamine
- BW 430C
- BW430C
- EINECS 281-901-8
- HSDB 7526
- Lamictal
- Lamictal CD
- Lamictal Odt
- Lamictal Xr
- Lamitor
- Lamotrigina
- Lamotrigina [Spanish]
- Lamotrigine
- Lamotriginum
- Lamotriginum [Latin]
- NSC 746307
- NSC 759171
- UNII-U3H27498KS
Systematic Names
- 1,2,4-Triazine-3,5-diamine, 6-(2,3-dichlorophenyl)-
- Lamotrigine
Registry Numbers
CAS Registry Number
- 84057-84-1
FDA UNII
- U3H27498KS
System Generated Number
- 0084057841
Structure Descriptors
InChI
InChI=1S/C9H7Cl2N5/c10-5-3-1-2-4(6(5)11)7-8(12)14-9(13)16-15-7/h1-3H,(H4,12,13,14,16)InChIKey
PYZRQGJRPPTADH-UHFFFAOYSA-NSmiles
Nc1nnc(c(N)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
man | TDLo | oral | 19mg/kg (19mg/kg) | CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) | Lancet. Vol. 342, Pg. 1552, 1993. |
man | TDLo | oral | 45mg/kg/25D-I (45mg/kg) | SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" | Journal of Clinical Psychiatry. Vol. 59, Pg. 87, 1998. |
mouse | LD50 | oral | 245mg/kg (245mg/kg) | Epilepsia Vol. 25, Pg. 655, 1984. | |
rat | LD50 | oral | 205mg/kg (205mg/kg) | Epilepsia Vol. 25, Pg. 655, 1984. | |
women | TDLo | oral | 2mg/kg/30H-I (2mg/kg) | GASTROINTESTINAL: NAUSEA OR VOMITING KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" | Pediatrics. Vol. 98, Pg. 294, 1996. |