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Substance Name: Sertraline hydrochloride [USAN:USP]
RN: 79559-97-0
UNII: UTI8907Y6X
InChIKey: BLFQGGGGFNSJKA-XHXSRVRCSA-N

Note

  • A selective serotonin uptake inhibitor that is used in the treatment of depression.

Molecular Formula

  • C17-H17-Cl2-N.Cl-H

Molecular Weight

  • 342.6952
 

Classification Codes

  • Antidepressant
  • Drug / Therapeutic Agent
  • Human Data
  • Reproductive Effect
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Names and Synonyms

Name of Substance

  • Sertraline hydrochloride [USAN:USP]

Synonyms

  • (1S,4S)-4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthylamine hydrochloride
  • Adjuvin
  • Atruline
  • Cp 51,974-1
  • Cp-51,974-1
  • Gladem
  • NSC 746308
  • NSC 758948
  • Serad
  • Sertraline HCl
  • Sertraline hydrochloride
  • Tatig
  • Tresleen
  • UNII-UTI8907Y6X
  • Zoloft

Systematic Name

  • 1-Naphthalenamine, 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-, hydrochloride, (1S-cis)-

Registry Numbers

CAS Registry Number

  • 79559-97-0

FDA UNII

  • UTI8907Y6X

Related Registry Number

  • 79617-96-2 (Parent)

System Generated Number

  • 0079559970

Molecular Formulas

Molecular Formula

  • C17-H17-Cl2-N.Cl-H

Molecular Formula Fragments

  • C17-H17-Cl2-N
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

InChI=1S/C17H17Cl2N.ClH/c1-20-17-9-7-12(13-4-2-3-5-14(13)17)11-6-8-15(18)16(19)10-11;/h2-6,8,10,12,17,20H,7,9H2,1H3;1H/t12-,17-;/m0./s1

InChIKey

BLFQGGGGFNSJKA-XHXSRVRCSA-N

Smiles

Cl.CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c3ccccc13

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
man TDLo oral 2857ug/kg (2.857mg/kg) BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"

GASTROINTESTINAL: NAUSEA OR VOMITING

SKIN AND APPENDAGES (SKIN): SWEATING: OTHER		 Shinkei Seishin Yakuri. Neuropsychopharmacology. Vol. 19, Pg. 395, 1997.
mouse LDLo intraperitoneal 56mg/kg (56mg/kg)   Drug and Chemical Toxicology. Vol. 21, Pg. 163, 1998.
mouse LDLo intraperitoneal 56mg/kg (56mg/kg) BEHAVIORAL: FOOD INTAKE (ANIMAL)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD		 Drug and Chemical Toxicology. Vol. 21, Pg. 163, 1998.
mouse LDLo oral 336mg/kg (336mg/kg) SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE

BEHAVIORAL: FOOD INTAKE (ANIMAL)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD		 Drug and Chemical Toxicology. Vol. 21, Pg. 163, 1998.
rat LDLo intraperitoneal 56mg/kg (56mg/kg)   Drug and Chemical Toxicology. Vol. 21, Pg. 163, 1998.
rat LDLo intraperitoneal 56mg/kg (56mg/kg) BEHAVIORAL: FOOD INTAKE (ANIMAL)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD		 Drug and Chemical Toxicology. Vol. 21, Pg. 163, 1998.
rat LDLo oral 840mg/kg (840mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

BEHAVIORAL: FOOD INTAKE (ANIMAL)		 Drug and Chemical Toxicology. Vol. 21, Pg. 163, 1998.
women TDLo oral 7mg/kg/2W-I (7mg/kg) BEHAVIORAL: HEADACHE

MUSCULOSKELETAL: CHANGES IN TEETH AND SUPPORTING STRUCTURES

SKIN AND APPENDAGES (SKIN): SWEATING: OTHER		 Journal of Clinical Psychiatry. Vol. 54, Pg. 432, 1993.
women TDLo oral 7mg/kg/7D-I (7mg/kg) BEHAVIORAL: EXCITEMENT Journal of Clinical Psychiatry. Vol. 54, Pg. 321, 1993.