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Substance Name: Isoniazid [USP:INN:BAN:JAN]
RN: 54-85-3
UNII: V83O1VOZ8L
InChIKey: QRXWMOHMRWLFEY-UHFFFAOYSA-N
Note
- Antibacterial agent used primarily as a tuberculostatic. It remains the treatment of choice for tuberculosis.
Molecular Formula
- C6-H7-N3-O
Molecular Weight
- 137.1413
- All
- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
Classification Codes
- Anti-Bacterial Agents
- Anti-Infective Agents
- Antibacterial (Tuberculostatic)
- Antimetabolites
- Antitubercular Agents
- Drug / Therapeutic Agent
- Fatty Acid Synthesis Inhibitors
- Human Data
- Hypolipidemic Agents
- Mutation Data
- Reproductive Effect
- Skin / Eye Irritant
- Tumor Data
Superlist Classification Code
- Overall Carcinogenic Evaluation: Group 3
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Links to Resources
NLM Resources (File Locators)
Regulatory Agencies (Superlist Locators)
Other Resources (Internet Locators)
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Names and Synonyms
Name of Substance
- Isoniazid
- Isoniazid [USP:INN:BAN:JAN]
MeSH Heading
- Isoniazid
Synonyms
- 4-(Hydrazinocarbonyl)pyridine
- 4-Pyridinecarbonylhydrazine
- 4-Pyridinecarboxylic acid, hydrazide
- 4-Pyridinecarboxylic hydrazide
- 4-Pyridylcarbonylhydrazide
- 5015 R.P.
- 5015 RP
- AI3-23936
- Amidon
- Andrazide
- Antimicina
- Antituberkulosum
- Armazid
- Armazide
- Atcotibine
- Azuren
- Bacillin
- BP 5015
- CCRIS 351
- Cedin
- Cedin (Aerosol)
- Cemidon
- Chemiazid
- Chemidon
- Cotinazin
- Defonin
- Diforin
- Dinacrin
- Ditubin
- Dow-isoniazid
- Ebidene
- EINECS 200-214-6
- Eralon
- Ertuban
- Eutizon
- Evalon
- Fimalene
- FSR 3
- FSR-3
- Ftivazide
- GInk
- HIA
- Hidranizil
- Hidrasonil
- Hidrulta
- Hidrun
- HSDB 1647
- Hycozid
- Hydrazid
- Hyzyd
- Ido-tebin
- Idrazide dell'acido isonicotinico
- Idrazide dell'acido isonicotinico [Italian]
- Idrazil
- IN-73
- INAH
- INH
- Inh-Burgthal
- Inizid
- Iscotin
- Isidrina
- Ismazide
- Isobicina
- Isocid
- Isocidene
- Isocotin
- Isohydrazide
- Isolyn
- Isonerit
- Isonex
- Isoniazid
- Isoniazid SA
- Isoniazida
- Isoniazida [INN-Spanish]
- Isoniazide
- Isoniazidum
- Isoniazidum [INN-Latin]
- Isonicid
- Isonico
- Isonicotan
- Isonicotil
- Isonicotinhydrazid
- Isonicotinic acid hydrazide
- Isonicotinic hydrazide
- Isonicotinohydrazide
- Isonicotinoyl hydrazide
- Isonicotinoylhydrazine
- Isonicotinsaeurehydrazid
- Isonicotinsaeurehydrazid [German]
- Isonicotinyl hydrazide
- Isonicotinylhydrazine
- Isonide
- Isonidrin
- Isonikazid
- Isonilex
- Isonin
- Isonindon
- Isonirit
- Isoniton
- Isonizide
- Isotamine
- Isotebe
- Isotebezid
- Isotinyl
- Isozid
- Isozide
- Isozyd
- L 1945
- Laniazid
- Mybasan
- Neo-tizide
- Neoteben
- Neoxin
- Neumandin
- Nevin
- Niadrin
- Nicazide
- Nicetal
- Nicizina
- Niconyl
- Nicotibina
- Nicotibine
- Nicotisan
- Nicozide
- Nidaton
- Nidrazid
- Nikozid
- Niplen
- Nitadon
- Niteban
- Nitebannsc 9659
- NSC 9659
- Nydrazid
- Nyscozid
- Pelazid
- Percin
- Phthisen
- Phthivazide
- Preparation 6424
- Pycazide
- Pyreazid
- Pyricidin
- Pyrizidin
- Raumanon
- Razide
- Retozide
- Rifamate
- Rimicid
- Rimifon
- Rimiphone
- Rimitsid
- RP-5015
- Stanozide
- Tubazid
- Tubazide
- UNII-V83O1VOZ8L
Systematic Names
- 4-Pyridinecarboxylic acid, hydrazide
- Isoniazid
- Isonicotinic acid hydrazide
Superlist Names
- Isoniazid
- Isonicotinic acid hydrazide
Mixture Name
- Rifater
Registry Numbers
CAS Registry Number
- 54-85-3
FDA UNII
- V83O1VOZ8L
Other Registry Numbers
- 37271-10-6
- 41466-07-3
- 62229-51-0
- 7640-37-1
System Generated Number
- 0000054853
Structure Descriptors
InChI
InChI=1S/C6H7N3O/c7-9-6(10)5-1-3-8-4-2-5/h1-4H,7H2,(H,9,10)InChIKey
QRXWMOHMRWLFEY-UHFFFAOYSA-NSmiles
NNC(=O)Toxicity
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| cat | LD50 | intraperitoneal | 325mg/kg (325mg/kg) | LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE | Klinische Wochenscrift. Vol. 30, Pg. 959, 1952. |
| child | TDLo | oral | 125mg/kg (125mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: COMA | Annals of Emergency Medicine. Vol. 17, Pg. 73, 1988. |
| child | TDLo | oral | 195mg/kg (195mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: HEADACHE | Japanese Journal of Toxicology. Vol. 12, Pg. 225, 1999. |
| child | TDLo | oral | 3600mg/kg/43W (3600mg/kg) | SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE BEHAVIORAL: ATAXIA BEHAVIORAL: TREMOR | Canadian Medical Association Journal. Vol. 148, Pg. 49, 1993. |
| dog | LD50 | oral | 50mg/kg (50mg/kg) | American Review of Tuberculosis. Vol. 65, Pg. 392, 1952. | |
| guinea pig | LD50 | intramuscular | 255mg/kg (255mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA | Schweizerische Zeitschrift fuer Tuberkulose und Pneumonologie. Vol. 9, Pg. 226, 1952. |
| guinea pig | LD50 | intraperitoneal | 195mg/kg (195mg/kg) | LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE | Klinische Wochenscrift. Vol. 30, Pg. 959, 1952. |
| guinea pig | LD50 | intravenous | 220mg/kg (220mg/kg) | GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" | Archiv fuer Toxikologie. Vol. 22, Pg. 80, 1966. |
| guinea pig | LD50 | oral | 255mg/kg (255mg/kg) | BEHAVIORAL: ATAXIA BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Schweizerische Zeitschrift fuer Tuberkulose und Pneumonologie. Vol. 9, Pg. 226, 1952. |
| guinea pig | LD50 | subcutaneous | 195mg/kg (195mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA | Schweizerische Zeitschrift fuer Tuberkulose und Pneumonologie. Vol. 9, Pg. 226, 1952. |
| human | LDLo | oral | 100mg/kg (100mg/kg) | PERIPHERAL NERVE AND SENSATION: STRUCTURAL CHANGE IN NERVE OR SHEATH | American Review of Respiratory Disease. Vol. 105, Pg. 206, 1972. |
| infant | TDLo | oral | 91mg/kg (91mg/kg) | BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Pediatrics. Vol. 95, Pg. 700, 1995. |
| man | LDLo | oral | 116mg/kg (116mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD CARDIAC: OTHER CHANGES LUNGS, THORAX, OR RESPIRATION: EMPHYSEMA | Journal of Analytical Toxicology. Vol. 16, Pg. 57, 1992. |
| man | LDLo | oral | 523mg/kg/17W- (523mg/kg) | LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), DIFFUSE" LIVER: "HEPATITIS, FIBROUS (CIRRHOSIS, POST-NECROTIC SCARRING)" | JAMA, Journal of the American Medical Association. Vol. 176, Pg. 877, 1961. |
| man | TDLo | oral | 39mg/kg/9D-I (39mg/kg) | SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" | Southern Medical Journal. Vol. 75, Pg. 81, 1982. |
| man | TDLo | oral | 100mg/kg/3W-C (100mg/kg) | BEHAVIORAL: ANOREXIA (HUMAN SKIN AND APPENDAGES (SKIN): SWEATING: OTHER KIDNEY, URETER, AND BLADDER: OTHER CHANGES | American Review of Respiratory Disease. Vol. 106, Pg. 849, 1972. |
| man | TDLo | oral | 430mg/kg (430mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: GENERAL ANESTHETIC | Neurology. Vol. 20, Pg. 299, 1970. |
| mouse | LD50 | intramuscular | 137mg/kg (137mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA | American Review of Tuberculosis. Vol. 65, Pg. 376, 1952. |
| mouse | LD50 | intraperitoneal | 100mg/kg (100mg/kg) | National Technical Information Service. Vol. AD277-689, | |
| mouse | LD50 | intravenous | 149mg/kg (149mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Journal of Pharmacology and Experimental Therapeutics. Vol. 122, Pg. 110, 1958. |
| mouse | LD50 | oral | 133mg/kg (133mg/kg) | LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | American Review of Tuberculosis. Vol. 65, Pg. 376, 1952. |
| mouse | LD50 | subcutaneous | 125mg/kg (125mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Yakugaku Zasshi. Journal of Pharmacy. Vol. 81, Pg. 1225, 1961. |
| rabbit | LD50 | intracrebral | > 12mg/kg (12mg/kg) | BEHAVIORAL: ATAXIA BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Schweizerische Zeitschrift fuer Tuberkulose und Pneumonologie. Vol. 9, Pg. 226, 1952. |
| rabbit | LD50 | intramuscular | 155mg/kg (155mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA | Schweizerische Zeitschrift fuer Tuberkulose und Pneumonologie. Vol. 9, Pg. 226, 1952. |
| rabbit | LD50 | intraperitoneal | 147mg/kg (147mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA | Schweizerische Zeitschrift fuer Tuberkulose und Pneumonologie. Vol. 9, Pg. 226, 1952. |
| rabbit | LD50 | intravenous | 94mg/kg (94mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | American Review of Tuberculosis. Vol. 65, Pg. 376, 1952. |
| rabbit | LD50 | oral | 250mg/kg (250mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 12, Pg. 22, 1962. | |
| rabbit | LD50 | subcutaneous | 135mg/kg (135mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA | Schweizerische Zeitschrift fuer Tuberkulose und Pneumonologie. Vol. 9, Pg. 226, 1952. |
| rat | LD50 | intramuscular | 400mg/kg (400mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Therapie. Vol. 8, Pg. 62, 1953. |
| rat | LD50 | intraperitoneal | 335mg/kg (335mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA | Schweizerische Zeitschrift fuer Tuberkulose und Pneumonologie. Vol. 9, Pg. 226, 1952. |
| rat | LD50 | intravenous | 365mg/kg (365mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 409, 1976. | |
| rat | LD50 | oral | 1250mg/kg (1250mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 409, 1976. | |
| rat | LD50 | subcutaneous | 329mg/kg (329mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 119, Pg. 444, 1957. | |
| women | TDLo | oral | 12mg/kg/2D-I (12mg/kg) | BEHAVIORAL: ATAXIA BEHAVIORAL: TOXIC PSYCHOSIS | Neurology. Vol. 34, Pg. 703, 1984. |
| women | TDLo | oral | 90200ug/kg/7D (90.2mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: HEADACHE CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE | Pediatrics. Vol. 97, Pg. 782, 1996. |
| women | TDLo | oral | 99300ug/kg (99.3mg/kg) | BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD GASTROINTESTINAL: NAUSEA OR VOMITING | Pediatrics. Vol. 95, Pg. 700, 1995. |
| women | TDLo | oral | 11250mg/kg (11250mg/kg) | BEHAVIORAL: COMA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Anaesthesia. Vol. 47, Pg. 781, 1992. |
Physical Properties
| Physical Property | Value | Units | Temp (deg C) | Source |
|---|---|---|---|---|
| Melting Point | 171.4 | deg C | EXP | |
| pKa Dissociation Constant | 1.82 | (none) | 20 | EXP |
| log P (octanol-water) | -0.7 | (none) | EXP | |
| Water Solubility | 1.40E+05 | mg/L | 25 | EXP |
| Vapor Pressure | 4.64E-05 | mm Hg | 25 | EST |
| Henry's Law Constant | 1.21E-14 | atm-m3/mole | 25 | EST |
| Atmospheric OH Rate Constant | 5.84E-12 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.