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Substance Name: Sulfadiazine, silver [USAN:USP]
RN: 22199-08-2
UNII: W46JY43EJR
InChIKey: UEJSSZHHYBHCEL-UHFFFAOYSA-N
Note
- Antibacterial used topically in burn therapy.
Molecular Formulas
- C10-H10-N4-O2-S.Ag
- C10-H9-Ag-N4-O2-S
Molecular Weight
- 357.1431
- All
- Classifications
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- Registry Numbers
- Formulas
- Structure Descriptors
- Toxicity
Classification Codes
- Anti-Infective Agents
- Anti-Infective Agents, Local
- Anti-Infective, Topical
- Drug / Therapeutic Agent
- Human Data
- Mutation Data
- Reproductive Effect
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Names and Synonyms
Name of Substance
- Silver sulfadiazine
- Sulfadiazine silver salt
- Sulfadiazine, silver [USAN:USP]
MeSH Heading
- Silver sulfadiazine
Synonyms
- 4-Amino-N-(2-pyrimidinyl)benzenesulfonamide silver salt
- Dermazin
- Dermazine
- EINECS 244-834-5
- Flamazine
- Geben
- N(sup 1)-2-Pyrimidinylsulfanilamide monosilver(1+) salt
- N1-2-Pyrimidinylsulfanilamide monosilver(1+) salt
- NSC 625324
- Silbertone
- Silvadene
- Silver sulfadiazine
- Silver sulphadiazine
- SSD
- SSD AF
- Sulfadiazin silber
- Sulfadiazin, silbersalz
- Sulfadiazine silver
- Sulfadiazine silver salt
- Sulfadiazine, Silver
- Sulfolex
- Thermazene
- UNII-W46JY43EJR
Systematic Names
- (4-Amino-N-pyrimidin-2-ylbenzenesulphonamidato-NN,O1)silver
- Benzenesulfonamide, 4-amino-N-2-pyrimidinyl-, monosilver(1+) salt
- Silver, (4-amino-N-2-pyrimidinylbenzenesulfonamidato-NN,O1)-
- Sulfanilamide, N(sup 1)-2-pyrimidinyl-, monosilver(1+) salt
Mixture Name
- SSD
Registry Numbers
CAS Registry Number
- 22199-08-2
FDA UNII
- W46JY43EJR
System Generated Number
- 0022199082
Molecular Formulas
Molecular Formulas
- C10-H10-N4-O2-S.Ag
- C10-H9-Ag-N4-O2-S
Molecular Formula Fragments
- Ag
- C10-H10-N4-O2-S
- COMPONENT
Structure Descriptors
InChI
InChI=1S/C10H9N4O2S.Ag/c11-8-2-4-9(5-3-8)17(15,16)14-10-12-6-1-7-13-10;/h1-7H,11H2;/q-1;+1InChIKey
UEJSSZHHYBHCEL-UHFFFAOYSA-NSmiles
[Ag+].Nc1ccc(cc1)Toxicity
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| man | TDLo | skin | 536mg/kg/21W- (536mg/kg) | PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) | Lancet. Vol. 340, Pg. 126, 1992. |
| mouse | LDLo | intraperitoneal | 550mg/kg (550mg/kg) | United States Patent Document. Vol. #4020150, | |
| mouse | LDLo | oral | > 10gm/kg (10000mg/kg) | Kiso to Rinsho. Clinical Report. Vol. 14, Pg. 2850, 1980. | |
| mouse | LDLo | oral | > 10gm/kg (10000mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) | Kiso to Rinsho. Clinical Report. Vol. 14, Pg. 2850, 1980. |
| mouse | LDLo | subcutaneous | > 10gm/kg (10000mg/kg) | BLOOD: CHANGES IN SPLEEN LIVER: OTHER CHANGES | Kiso to Rinsho. Clinical Report. Vol. 14, Pg. 2850, 1980. |
| rat | LD50 | intraperitoneal | 126mg/kg (126mg/kg) | BLOOD: CHANGES IN SPLEEN LIVER: OTHER CHANGES SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" | Kiso to Rinsho. Clinical Report. Vol. 14, Pg. 2850, 1980. |
| rat | LD50 | oral | > 10gm/kg (10000mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 13, Pg. 637, 1982. | |
| rat | LD50 | unreported | 160mg/kg (160mg/kg) | United States Patent Document. Vol. #4535078, | |
| rat | LDLo | subcutaneous | > 10gm/kg (10000mg/kg) | LIVER: OTHER CHANGES BLOOD: CHANGES IN SPLEEN | Kiso to Rinsho. Clinical Report. Vol. 14, Pg. 2850, 1980. |