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Substance Name: Pelitinib [USAN:INN]
RN: 257933-82-7
UNII: X5DWL380Z6
InChIKey: WVUNYSQLFKLYNI-AATRIKPKSA-N

Notes

  • An EGF receptor kinase inhibitor.
  • An EGF receptor kinase inhibitor.

    NCI: A substance being studied in the treatment of some types of cancer. It blocks the action of certain proteins that are part of the epidermal growth factor receptor (EGFR) family of proteins. These proteins may be found in increased amounts on the surface of some types of cancer cells. Blocking the action of these proteins may stop cancer cells from growing and may kill cancer cells. Pelitinib is a type of EGFR inhibitor. Also called EKB-569.
  • NCI: A substance being studied in the treatment of some types of cancer. It blocks the action of certain proteins that are part of the epidermal growth factor receptor (EGFR) family of proteins. These proteins may be found in increased amounts on the surface of some types of cancer cells. Blocking the action of these proteins may stop cancer cells from growing and may kill cancer cells. Pelitinib is a type of EGFR inhibitor. Also called EKB-569.

Molecular Formula

  • C24-H23-Cl-F-N5-O2

Molecular Weight

  • 467.9297
 

Classification Codes

  • Antineoplastic Agents
  • Enzyme Inhibitors
  • Protein Kinase Inhibitors
  • Treatment of Cancer
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Names and Synonyms

Name of Substance

  • EKB 569
  • Pelitinib [USAN:INN]

Synonyms

  • (2E)-N-(4-((3-chloro-4-fluorophenyl)amino)-3-cyano-7-ethoxy-6-quinolinyl)-4-(dimethylamino)-2-butenamide
  • (2E)-N-(4-((3-Chloro-4-fluorophenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)but-2-enamide
  • 2-Butenamide, N-(4-((3-chloro-4-fluorophenyl)amino)-3-cyano-7-ethoxy-6-quinolinyl)-4-(dimethylamino)-, (2E)-
  • EKB-569
  • EKI 569
  • EKI-569
  • Pelitinib
  • UNII-X5DWL380Z6
  • WAY-EKB 569

Systematic Name

  • 2-Butenamide, N-(4-((3-chloro-4-fluorophenyl)amino)-3-cyano-7-ethoxy-6-quinolinyl)-4-(dimethylamino)-, (2E)-

Registry Numbers

CAS Registry Number

  • 257933-82-7

FDA UNII

  • X5DWL380Z6

System Generated Number

  • 0257933827

Structure Descriptors

InChI

InChI=1S/C24H23ClFN5O2/c1-4-33-22-12-20-17(11-21(22)30-23(32)6-5-9-31(2)3)24(15(13-27)14-28-20)29-16-7-8-19(26)18(25)10-16/h5-8,10-12,14H,4,9H2,1-3H3,(H,28,29)(H,30,32)/b6-5+

InChIKey

WVUNYSQLFKLYNI-AATRIKPKSA-N

Smiles

CCOc1cc2ncc(C#N)c(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)\C=C\CN(C)C