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Substance Name: Glipizide [USAN:USP:INN:BAN]
RN: 29094-61-9
UNII: X7WDT95N5C
InChIKey: ZJJXGWJIGJFDTL-UHFFFAOYSA-N

Note

  • An oral hypoglycemic agent which is rapidly absorbed and completely metabolized.

Molecular Formula

  • C21-H27-N5-O4-S

Molecular Weight

  • 445.5413
 

Classification Codes

  • Antidiabetic
  • Drug / Therapeutic Agent
  • Human Data
  • Hypoglycemic Agents

Names and Synonyms

Name of Substance

  • Glipizide
  • Glipizide [USAN:USP:INN:BAN]

MeSH Heading

  • Glipizide

Synonyms

  • 1-Cyclohexyl-3-((p-(2-(5-methylpyrazinecarboxamido)ethyl)phenyl)sulfonyl)urea
  • Aldiab
  • Apamid
  • BRN 0903495
  • CP 28,720
  • CP 28720
  • CP-28,720
  • Digrin
  • Dipazide
  • EINECS 249-427-6
  • Glibenese
  • Glibetin
  • Glican
  • Glide
  • Glidiab
  • Glipid
  • Glipizida
  • Glipizida [INN-Spanish]
  • Glipizide
  • Glipizidum
  • Glipizidum [INN-Latin]
  • Gluco-Rite
  • Glucolip
  • Glucotrol
  • Glucotrol XL
  • Glucozide
  • Glupitel
  • Glupizide
  • Glyde
  • Glydiazinamide
  • K 4024
  • Melizide
  • Mindiab
  • Minidab
  • Minidiab
  • Minodiab
  • N-(4-(beta-(5-Methylpyrazine-2-carboxamido)ethyl)benzenesulphonyl)-N'-cyclohexylurea
  • Napizide
  • NSC 759120
  • Ozidia
  • Pyrazinecarboxamide, N-(2-(4-((((cyclohexylamino)carbonyl)amino)sulfonyl)phenyl)ethyl)-5-methyl-
  • Sucrazide
  • TK 1320
  • UNII-X7WDT95N5C

Systematic Names

  • Glipizide
  • Pyrazinecarboxamide, N-(2-(4-((((cyclohexylamino)carbonyl)amino)sulfonyl)phenyl)ethyl)-5-methyl-
  • Urea, 1-cyclohexyl-3-((p-(2-(5-methylpyrazinecarboxamido)ethyl)phenyl)sulfonyl)-

Mixture Name

  • Metaglip

Registry Numbers

CAS Registry Number

  • 29094-61-9

FDA UNII

  • X7WDT95N5C

Other Registry Numbers

  • 172964-66-8
  • 29094-66-4
  • 38777-27-4

System Generated Number

  • 0029094619

Structure Descriptors

InChI

InChI=1S/C21H27N5O4S/c1-15-13-24-19(14-23-15)20(27)22-12-11-16-7-9-18(10-8-16)31(29,30)26-21(28)25-17-5-3-2-4-6-17/h7-10,13-14,17H,2-6,11-12H2,1H3,(H,22,27)(H2,25,26,28)

InChIKey

ZJJXGWJIGJFDTL-UHFFFAOYSA-N

Smiles

Cc1cnc(cn1)C(=O)NCCc2ccc(cc2)S(=O)(=O)NC(=O)NC3CCCCC3

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
child TDLo oral 379ug/kg (0.379mg/kg) ENDOCRINE: HYPOGLYCEMIA Annals of Emergency Medicine. Vol. 31, Pg. 773, 1998.
guinea pig LD50 intraperitoneal 2400mg/kg (2400mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 21, Pg. 208, 1971.
guinea pig LDLo oral > 4gm/kg (4000mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 21, Pg. 208, 1971.
mouse LD50 intraperitoneal > 3gm/kg (3000mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 21, Pg. 208, 1971.
mouse LDLo oral > 4gm/kg (4000mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 21, Pg. 208, 1971.
rat LD50 intraperitoneal 1200mg/kg (1200mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 21, Pg. 208, 1971.
rat LDLo oral > 4gm/kg (4000mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 21, Pg. 208, 1971.

Physical Properties

Physical Property Value Units Temp (deg C) Source
pKa Dissociation Constant 5.9 (none)   EXP
log P (octanol-water) 1.91 (none)   EXP
Water Solubility 37.2 mg/L 25 EST
Vapor Pressure 2.73E-16 mm Hg 25 EST
Henry's Law Constant 1.03E-20 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 3.42E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.