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Substance Name: Sucralfate [USAN:USP:INN:BAN:JAN]
RN: 54182-58-0
UNII: XX73205DH5
InChIKey: IPLJAZDIICJQEL-JTJNLBSYSA-A

Note

  • A basic aluminum complex of sulfated sucrose.

Molecular Formula

  • C12-H54-Al16-O75-S8

Molecular Weight

  • 1558.7195
 

Classification Codes

  • Anti-Ulcer Agents
  • Anti-Ulcerative (Gastrointestinal)
  • Drug / Therapeutic Agent
  • Gastrointestinal Agents
  • Human Data

Names and Synonyms

Name of Substance

  • Sucralfate
  • Sucralfate [USAN:USP:INN:BAN:JAN]

MeSH Heading

  • Sucralfate

Synonyms

  • 1,2,3,3',4,4',6,6'-Octa-O-sulfo-beta-D-fructofuranosyl-alpha-D-glucopyranosid aluminium hydroxid-hydrat-salz
  • Antepsin
  • Carafate
  • EINECS 259-018-4
  • Hexadeca-U-hydroxytetracosahydroxy-(U8-(1,3,4,6-tetra-O-sulfo-beta-D-fructofuranosyl-alpha-D-glucopyranoside tetrakis(hydrogen sulfato)(8-))) hexadecaaluminum
  • HSDB 3926
  • OGA-6J
  • OS 202
  • Sucralfate
  • Sucralfato
  • Sucralfato [INN-Spanish]
  • Sucralfatum
  • Sucralfatum [INN-Latin]
  • Sucrose hydrogen sulfate basic aluminium salt
  • Sucrose octakis(hydrogen sulfate) aluminum complex
  • Ulcar
  • Ulcerban
  • Ulcerlmin
  • Ulcogant
  • UNII-XX73205DH5

Systematic Names

  • alpha-D-Glucopyranoside, beta-D-fructofuranosyl-, octakis(hydrogen sulfate), aluminum complex
  • Aluminum, hexadeca-mu-hydroxytetracosahydroxy(mu8-(1,3,4,6-tetra-O-sulfo-beta-D-fructofuranosyl alpha-D-glucopyranoside tetrakis(hydrogen sulfato)(8-)))hexadeca-
  • Sucralfate

Registry Numbers

CAS Registry Number

  • 54182-58-0

FDA UNII

  • XX73205DH5

System Generated Number

  • 0054182580

Structure Descriptors

InChI

InChI=1S/C12H22O35S8.9Al.20H2O/c13-48(14,15)37-1-4-6(43-51(22,23)24)8(45-53(28,29)30)9(46-54(31,32)33)11(40-4)42-12(3-39-50(19,20)21)10(47-55(34,35)36)7(44-52(25,26)27)5(41-12)2-38-49(16,17)18;;;;;;;;;;;;;;;;;;;;;;;;;;;;;/h4-11H,1-3H2,(H,13,14,15)(H,16,17,18)(H,19,20,21)(H,22,23,24)(H,25,26,27)(H,28,29,30)(H,31,32,33)(H,34,35,36);;;;;;;;;;20*1H2/q;9*+3;;;;;;;;;;;;;;;;;;;;/p-27/t4-,5-,6-,7-,8+,9-,10+,11-,12+;;;;;;;;;;;;;;;;;;;;;;;;;;;;;/m1............................./s1

InChIKey

IPLJAZDIICJQEL-JTJNLBSYSA-A

Smiles

O.O[Al](O)O.O[Al](O)OS(=O)(=O)OC[C@H]1O[C@H](O[C@]2(COS(=O)(=O)O[Al](O)O)O[C@H](COS(=O)(=O)O[Al](O)O)[C@@H](OS(=O)(=O)O[Al](O)O)[C@@H]2OS(=O)(=O)O[Al](O)O)[C@H](OS(=O)(=O)O[Al](O)O)[C@@H](OS(=O)(=O)O[Al](O)O)[C@@H]1OS(=O)(=O)O[Al](O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
infant TDLo oral 1276mg/kg/3D- (1276mg/kg) CARDIAC: PULSE RATE Clinical Pediatrics Vol. 35, Pg. 423, 1996.
mouse LD50 intraperitoneal > 8gm/kg (8000mg/kg)   Drugs in Japan Vol. 6, Pg. 374, 1982.
mouse LD50 oral > 8gm/kg (8000mg/kg)   Drugs in Japan Vol. 6, Pg. 374, 1982.
mouse LD50 subcutaneous > 8gm/kg (8000mg/kg)   Drugs in Japan Vol. 6, Pg. 374, 1982.
rat LD50 intraperitoneal > 4gm/kg (4000mg/kg)   Drugs in Japan Vol. 6, Pg. 374, 1982.
rat LD50 oral > 12gm/kg (12000mg/kg)   Drugs in Japan Vol. 6, Pg. 374, 1982.
rat LD50 subcutaneous > 4gm/kg (4000mg/kg)   Drugs in Japan Vol. 6, Pg. 374, 1982.