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Substance Name: Azanidazole [USAN:INN:BAN]
RN: 62973-76-6
UNII: YP2Y0DRX4S
InChIKey: LHIALLMPKJMSIQ-NSCUHMNNSA-N

Classification Codes

  • Antiprotozoal
  • Drug / Therapeutic Agent
  • Mutation Data
  • Reproductive Effect

Molecular Formula

  • C10-H10-N6-O2

Molecular Weight

  • 246.229
 
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Names and Synonyms

Name of Substance

  • Azanidazole
  • Azanidazole [USAN:INN:BAN]

Synonyms

  • (E)-2-Amino-4-(2-(1-methyl-5-nitroimidazol-2-yl)vinyl)pyrimidine
  • 2-Pyrimidinamine, 4-(2-(1-methyl-5-nitro-1H-imidazol-2-yl)ethenyl)-, (E)-
  • 4-((E)-2-(1-Methyl-5-nitro-1H-imidazol-2-yl)-aethenyl)-2-pyrimidinamin
  • 4-((E)-2-(1-Methyl-5-nitro-1H-imidazol-2-yl)-aethenyl)-2-pyrimidinamin [German]
  • 4-((E)-2-(1-Methyl-5-nitro-1H-imidazol-2-yl)-ethenyl)-2-pyrimidinamine
  • Azanidazol
  • Azanidazol [INN-Spanish]
  • Azanidazole
  • Azanidazolum
  • Azanidazolum [INN-Latin]
  • BRN 4495385
  • Nitromidine
  • Pyrimidine, 2-amino-4-((E)-2-(1-methyl-5-nitro-1H-imidazol-2-yl)ethenyl)-
  • Triclose
  • UNII-YP2Y0DRX4S

Systematic Names

  • 2-Pyrimidinamine, 4-(2-(1-methyl-5-nitro-1H-imidazol-2-yl)ethenyl)-, (E)-
  • 4-(2-(1-Methyl-5-nitro-1H-imidazol-2-yl)ethenyl)-2-pyrimidinamine (E)

Registry Numbers

CAS Registry Number

  • 62973-76-6

FDA UNII

  • YP2Y0DRX4S

System Generated Number

  • 0062973766

Structure Descriptors

InChI

InChI=1S/C10H10N6O2/c1-15-8(13-6-9(15)16(17)18)3-2-7-4-5-12-10(11)14-7/h2-6H,1H3,(H2,11,12,14)/b3-2+

InChIKey

LHIALLMPKJMSIQ-NSCUHMNNSA-N

Smiles

Cn1c(\C=C\c2ccnc(N)n2)ncc1[N+](=O)[O-]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 500mg/kg (500mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 21, Pg. 516, 1979.
mouse LD50 oral 5100mg/kg (5100mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: IRRITABILITY

BEHAVIORAL: ATAXIA
Arzneimittel-Forschung. Drug Research. Vol. 28, Pg. 2251, 1978.
rat LD50 intraperitoneal 860mg/kg (860mg/kg) BEHAVIORAL: IRRITABILITY

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ATAXIA
Arzneimittel-Forschung. Drug Research. Vol. 28, Pg. 2251, 1978.
rat LD50 oral 7600mg/kg (7600mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: IRRITABILITY
Arzneimittel-Forschung. Drug Research. Vol. 28, Pg. 2251, 1978.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 232-235 deg C   EXP
log P (octanol-water) 0.85 (none)   EXP
Water Solubility 1900 mg/L 25 EST
Vapor Pressure 6.60E-09 mm Hg 25 EST
Henry's Law Constant 4.93E-12 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 7.14E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.