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Substance Name: Sulfamonomethoxine sodium
RN: 38006-08-5
UNII: YY7L7A5XHO
InChIKey: IZJAOWYNDLDRKM-UHFFFAOYSA-N

Note

  • Long acting sulfonamide antibacterial agent.

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C11-H12-N4-O3-S.Na

Molecular Weight

  • 302.2889
 
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Names and Synonyms

Results Name

  • Sulfamonomethoxine sodium

Name of Substance

  • Sulfamonomethoxine sodium

Synonyms

  • 4-Methoxy-6-sulfanilamidopyrimidine sodium salt
  • DS-36 Sodium Salt
  • Sodium sulfamonomethoxine
  • Sulfamonomethoxine sodium salt
  • UNII-YY7L7A5XHO

Systematic Names

  • Benzenesulfonamide, 4-amino-N-(6-methoxy-4-pyrimidinyl)-, sodium salt
  • Sulfanilamide, N(sup 1)-(6-methoxy-4-pyrimidinyl)-, sodium salt

Registry Numbers

CAS Registry Number

  • 38006-08-5

FDA UNII

  • YY7L7A5XHO

System Generated Number

  • 0038006085

Molecular Formulas

Molecular Formula

  • C11-H12-N4-O3-S.Na

Molecular Formula Fragments

  • C11-H12-N4-O3-S
  • COMPONENT
  • Na

Structure Descriptors

InChI

1S/C11H11N4O3S.Na/c1-18-11-6-10(13-7-14-11)15-19(16,17)9-4-2-8(12)3-5-9;/h2-7H,12H2,1H3;/q-1;+1

InChIKey

IZJAOWYNDLDRKM-UHFFFAOYSA-N

Smiles

COc1cc(ncn1)[N-]S(=O)(=O)c2ccc(cc2)N.[Na+]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
chicken LD50 intravenous 1380mg/kg (1380mg/kg) LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA

BEHAVIORAL: FOOD INTAKE (ANIMAL)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Oyo Yakuri. Pharmacometrics. Vol. 9, Pg. 133, 1975.
chicken LD50 oral 7250mg/kg (7250mg/kg) LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA

BEHAVIORAL: FOOD INTAKE (ANIMAL)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Oyo Yakuri. Pharmacometrics. Vol. 9, Pg. 133, 1975.
dog LD50 intravenous 792mg/kg (792mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING

LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Oyo Yakuri. Pharmacometrics. Vol. 9, Pg. 133, 1975.
mouse LD50 intraperitoneal 1070mg/kg (1070mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 58, Pg. 59, 1962.
mouse LD50 intravenous 1010mg/kg (1010mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 58, Pg. 59, 1962.
mouse LD50 oral 3240mg/kg (3240mg/kg)   Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 58, Pg. 59, 1962.
mouse LD50 subcutaneous 1gm/kg (1000mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 58, Pg. 59, 1962.
rabbit LD50 intravenous 1530mg/kg (1530mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Oyo Yakuri. Pharmacometrics. Vol. 9, Pg. 133, 1975.
rat LD50 intravenous 1710mg/kg (1710mg/kg) LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: IRRITABILITY
Oyo Yakuri. Pharmacometrics. Vol. 9, Pg. 133, 1975.
rat LD50 oral 5620mg/kg (5620mg/kg) LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA

BEHAVIORAL: IRRITABILITY

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Oyo Yakuri. Pharmacometrics. Vol. 9, Pg. 133, 1975.
rat LD50 subcutaneous 1730mg/kg (1730mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA

BEHAVIORAL: IRRITABILITY
Oyo Yakuri. Pharmacometrics. Vol. 9, Pg. 133, 1975.